Palladium-catalysed cyclisation of alkenols: Synthesis of oxaheterocycles as core intermediates of natural compounds

Palladium-catalysed cyclisation of alkenols: Synthesis of oxaheterocycles as core intermediates of natural compounds

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Milk Thistle The study of Pd-catalysed cyclisation reactions of alkenols using different catalytic systems is reported.These transformations affect the stereoselective construction of mono- and/or bicyclic oxaheterocyclic derivatives depending on a starting alkenol.The substrate scope and proposed mechanism of Pd-catalysed cyclisation reactions are also discussed.Moreover, the diastereoselective Pd-catalysed cyclisation of appropriate alkenols to tetrahydrofurans and subsequent cyclisation provided properly substituted 2,5-dioxabicyclo[2.

2.1]heptane and 2,6-dioxabicyclo[3.2.1]octane, respectively.

Such bicyclic ring VAGABOND ESSENTIAL OIL subunits are found in many natural products including ocellenynes and aurovertines.